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The Impact Of Pharmacogenetics In Pharmaceutical Industry

Guest post by: Charles Godbout

Article Overview: Researchers who investigate the genetic variation of an individual and its reactions to medicines are hoping that the future medicines will be formulated with greater efficacy at a cost-effective rate, and with the least occurrence of serious adverse reactions.

The Impact Of Pharmacogenetics In Pharmaceutical Industry

Researchers who investigate the genetic variation of an individual and its reactions to medicines are hoping that the future medicines will be formulated with greater efficacy at a cost-effective rate, and with the least occurrence of serious adverse reactions. With the knowledge gained from the scientific investigation, the medicines prescribed by doctors will be personalized-based on the genetic constitution of an individual. As deeper the research goes, the more in-depth knowledge the scientists would obtain, which would influence the way the pharmaceutical companies design, formulate and sell drugs for people having specific genetic profiles.

Drugs tested solely in patients who would likely to benefit from it could centralize its development and magnify its therapeutic advantages.

The United States Food and Drug Administration goes beyond monitoring the safety of all drugs in the country, it recognizes the pharmacogenetics to be an invaluable tool in developing new medical products. Of late, the FDA has issued an approval on a number of genotyping kits pertinent to pharmacogenetics. This includes the test that identifies the variants in the cytochrome P450 enzymes that process several kinds of drugs. In many circumstances, the FDA suggests, but does not require the companies to submit the genetic data-which were developed based on the new science-with new drug applications.

Besides the pharmaceutical industry, the Healthcare provider will also be affected with the completion of the Human Genome Project and pharmacogenetics in the sense that the physicians will have the right tool to determine the right dose of the right medicine at first time or prescription for everybody. To simplify matters, the new science of genetics and pharmacology will result to safer and more efficacious medicines, not to mention having the least side effects, and at the cost-efficient rate.

Moreover, if the scientists could pinpoint the genetic basis for some toxic adverse reactions, the drugs could be prescribed exclusively to people who are not genetically at risk for such adverse reactions. In turn, this could keep the availability of promising medications that might have otherwise been taken off the market.

Although the knowledge gained from pharmacogenetics can be a useful tool for physicians in finding the best dose of the most suitable medicine for every patient, the physicians are not likely to rely on it solely. There are other factors that should be considered including the characteristics of the disease, and the patient's diet, weight, lifestyle, and other medicines that she or he is taking.

In April of 2000, the National Institutes of Health launched the pharmacogenetics Research Network or PGRN.

It is a countrywide collaboration of hundreds of scientists who concentrated on understanding how genes affect the way each individual responds to a certain medicine. From its inception, the scientists from the PGRN have examined the genes and medications pertinent to a wide variety of illnesses including depression, asthma, cancer and heart disease.

A key composition of the PGRN is the Pharmacogenetics Knowledge Base, which is an online resource that composes of pharmacogenetic information from the PGRN and other institutions. And this is readily and freely available to everyone who wants to do researches.

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Article Tags: pharmacogenetics
Referred by: http://jaykubassek.com



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